Use of rifamycin derivatives for the manufacture of a...

Details Use of rifamycin derivatives for the manufacture of a... Use of rifamycin derivatives for the manufacture of a...

A - Human Necessities

61

K

A61K 31/445 (2006.01) A61K 31/435 (2006.01) A61K 31/4353 (2006.01) A61K 31/438 (2006.01) A61K 31/71 (1990.01)

Patent

CA 2138643

A method of reducing the severity of toxoplasmosis resulting from infection of a patient with Toxoplasma gondii by administering to a patient in need of such treatment, either after infection or before exposure to infection, a therapeutically effective amount of a compound that is a spiropiperidyl derivative of rifamycin S, wherein the derivative comprises an imidazole ring that includes carbons at positions 3 and 4 of the rifamycin ring, the carbon at position 2 of the imidazole ring also being a ring carbon at position 4 of a piperidine ring system, thereby forming a spiropiperidyl ring system, the spiropiperidyl ring system optionally comprising a lower hydrocarbon substituent on the nitrogen of the piperidine.

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