Use of ritonavir for the treatment of unconjugated...

A - Human Necessities – 61 – K

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A61K 31/426 (2006.01) A61K 38/55 (2006.01) A61P 1/16 (2006.01)

Patent

CA 2517831

The present invention is directed to a method for inducing UGT1A1 isoform expression for treatment of a disease, disorder or adverse effect caused by an elevated serum concentration of an UGT1A1 substrate comprising the step of administering to a subject an effective amount of ritonavir. In particular, the present invention is directed to a method of treating unconjugated hyperbilirubinemia by UGT1A1 induction comprising the step of administering to a subject an effective amount of ritonavir.

La présente invention concerne une méthode visant à induire l'expression de l'isoforme UGT1A1 pour le traitement d'une maladie, d'un trouble ou d'un effet indésirable généré par une concentration sérique élevée d'un substrat UGT1A1, laquelle méthode consiste à administrer à un sujet une quantité efficace de ritonavir. Cette invention concerne en particulier une méthode de traitement d'une hyperbilirubinémie indirecte par induction de UGT1A1, laquelle méthode consiste à administrer à un sujet une quantité efficace de ritonavir.

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