Use of scf and g-csf in the treatment of cerebral ischemia...

Details Use of scf and g-csf in the treatment of cerebral ischemia... Use of scf and g-csf in the treatment of cerebral ischemia...

A - Human Necessities

61

K

A61K 38/19 (2006.01) A61P 25/00 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2586365

The present invention relates to the use of stem cell factor (SCF) polypeptide, alone and in combination with granulocyte colony stimulating factor (G~CSF) polypeptide, in the prevention or treatment of injury to the brain after cerebral ischemia or neurological disorder. More particularly, the invention provides methods of improving neurological function and outcome after stroke by the administration of SCF polypeptide, alone and in combination with G-CSF polypeptide. This treatment can be used alone or in combination with other well-known methods of treatment of cerebral ischemia and neurological disorders in a mammal.

L'invention concerne l'utilisation du polypeptide SCF (facteur des cellules souches), seul ou combiné au polypeptide G-CSF (facteur stimulant les colonies de granulocytes), pour la prévention ou le traitement des lésions cérébrales consécutives à une ischémie cérébrale ou à un trouble neurologique. D'une manière plus spécifique, l'invention concerne des méthodes qui permettent d'améliorer la fonction neurologique et les séquelles d'une apoplexie grâce à l'administration du polypeptide SCF, seul ou combiné au polypeptide G-CSF. Ce traitement peut être utilisé seul ou combiné à d'autres méthodes bien connues de traitement de l'ischémie cérébrale et des troubles neurologiques chez un mammifère.

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