Use of selected modulators of p2 purinoceptors for the...

Details Use of selected modulators of p2 purinoceptors for the... Use of selected modulators of p2 purinoceptors for the...

A - Human Necessities

61

K

A61K 31/53 (2006.01) A61P 9/10 (2006.01)

Patent

CA 2352789

Use of compounds modulating P2 purinoceptors, in particular antagonists such as Basilen Blue E-3G (Reactive Blue 2), for the prevention of the damages due to global cerebral ischemia and ischemia-reperfusion. Said compounds reduce the mortality in case of global cerebral ischemia as well as the neuronal damage of the hippocampus.

L'invention se rapporte à l'utilisation de composés modulant les purinocepteurs P¿2?, notamment de composés tels que les antagonistes du type Basilen Blue E-3G (Bleu chimiquement actif 2), dans le but de prévenir les lésions provoquées par une ischémie cérébrale globale et une reperfusion ischémique. Ces composés permettent de réduire la mortalité par ischémie cérébrale globale ainsi que les lésions neuronales de l'hippocampe.

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