Use of selectin-binding pregnancy proteins, liposomes,...

A - Human Necessities – 61 – K

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Details

A61K 38/17 (2006.01) A61K 9/127 (2006.01) A61K 31/7012 (2006.01) A61K 35/50 (2006.01) A61K 38/02 (2006.01) A61K 38/24 (2006.01) A61K 38/40 (2006.01) A61K 39/395 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07K 16/42 (2006.01)

Patent

CA 2428141

The invention relates to the use of selectin-binding active ingredients, in the form of pregnancy proteins or fragments thereof, liposomes containing calcium-binding compounds, mucin fragments originating from native sources or derived from the same, or mimetic compounds imitating sialylated Lewis carbohydrate structures, or combinations thereof, for the treatment and prophylaxis of diseases in the development of which inflammatory processes play a role, for example, auto-immune diseases, transplantations, and arteriosclerosis. Inflammatory diseases in terms of the invention can be of an infectious or non-infectious nature. The invention also relates to the use of said active ingredients for partially or fully preventing the metastatic spread of tumours. The administration of the active ingredients can be carried out in a prophylactic manner or in conjunction with, for example, an ablation of the primary tumour or a biopsy. The invention further relates to the use of said active ingredients for the prophylaxis of tumour diseases.

L'invention concerne l'utilisation de principes actifs fixant la sélectine, se présentant sous la forme de protéines produites pendant la grossesse ou de fragments de ces dernières, de liposomes contenant des composés fixant le calcium, de fragments de mucine provenant de sources natives ou dérivés de ces dernières, ou de composés mimétiques qui imitent les structures hydrate de carbone sialylées de type Lewis, ou de leurs combinaisons pour traiter et prévenir des maladies dans l'évolution desquelles des processus infectieux jouent un rôle, par exemple des maladies auto-immunes, des transplantations et l'artériosclérose. Les maladies mentionnées peuvent être de nature infectieuse ou non. L'invention concerne également l'utilisation de ces principes actifs pour empêcher partiellement ou totalement la métastatisation de tumeurs, l'administration des principes actifs pouvant être réalisée de manière prophylactique ou en combinaison par exemple avec une ablation de la tumeur primaire ou avec une biopsie. L'invention concerne en outre l'utilisation de ces principes actifs pour prévenir des maladies tumorales.

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