Use of selective cox-2 inhibitors for the treatment of...

Details Use of selective cox-2 inhibitors for the treatment of... Use of selective cox-2 inhibitors for the treatment of...

A - Human Necessities

61

K

A61K 31/5415 (2006.01) A61K 31/00 (2006.01) A61K 31/18 (2006.01) A61K 31/365 (2006.01) A61K 31/415 (2006.01) A61K 31/4162 (2006.01) A61K 31/42 (2006.01) A61K 31/427 (2006.01) A61K 31/4439 (2006.01) A61K 31/444 (2006.01) A61P 13/00 (2006.01) C12Q 1/26 (2006.01)

Patent

CA 2443031

Compounds that significantly inhibit the COX-2 isozyme and exhibit an inhibitory potency for the COX-2 isozyme that is at least 10-fold greater than the inhibitory potency said compound exhibits for the COX-2 isozyme are useful for the preparation of medicaments for the treatment of neuromuscular dysfunction of the lower urinary tract.

La présente invention se rapporte à des composés qui inhibent de manière significative l'isoenzyme COX-2 et présentent une capacité inhibitrice de cette iso-enzyme COX-2 qui est au moins dix fois supérieure à la capacité inhibitrice que ce composé présente vis-à-vis de l'isoenzyme COX-1. Ces composés s'avèrent utiles pour la préparation de médicaments destinés au traitement des dysfonctionnements neuromusculaires de voies urinaires inférieures.

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