Use of semaphorin for modulation of cellular efflux

Details Use of semaphorin for modulation of cellular efflux Use of semaphorin for modulation of cellular efflux

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01) A61K 38/17 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01) C07K 14/705 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2384104

The present invention is directed to compositions and methods comprising the use of semaphorins, semaphorin receptors, and polynucleotides encoding semaphorins and semaphorin receptors, for the modulation of cellular efflux mumps. Included in the present invention are compositions and methods for control of multiple drug resistance phenotypes via control of cellular efflux.

La présente invention concerne des compositions et des procédés comprenant l'utilisation de sémaphorines, de récepteurs à sémaphorines, et de polynucléotides codant pour des sémaphorines et des récepteurs à sémaphorines, pour la modulation de pompes à efflux cellulaire. Cette invention concerne également des compositions et des procédés permettant de contrôler des phénotypes à résistance médicamenteuse multiple par contrôle de l'efflux cellulaire.

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