A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/00 (2006.01) A61K 47/42 (2006.01)
Patent
CA 2548202
The in vivo and in vitro use of Invaplex to transport materials, including functional proteins and biologically active nucleic acids, across eukaryotic cell membranes. The eukaryotic cells include a variety of cell types, e.g. insect, reptile, fish, mammal and tumor cells. The suitable materials for transport include biochemicals such as reporter molecules, antibiotics, biopharmaceuticals and carbohydrates including polysaccharides, lipopolysaccharides, polynucleotides, such as DNA and RNA, and glycoproteins and proteins including antigens, enzymes, antibodies, receptors and hormones. In addition, Invaplex enhances the immune response to DNA vaccines and also can function by itself as a vaccine against shigellosis.
L'invention concerne l'utilisation in vivo et in vitrod'un complexe d'invasine (Invaplex) pour transporter des matériaux, notamment des protéines fonctionnelles et des acides nucléiques biologiquement actifs, sur des membranes de cellules eucaryotes. Parmi les cellules eucaryotes, on trouve une variété de types de cellules, par exemple des cellules d'insectes, de reptiles, de poissons, de mammifères et de tumeurs. A titre de matériaux appropriés pour le transport, on peut citer des molécules rapporteuses, des antibiotiques, des agents biopharmaceutiques et des hydrates de carbone, y compris des polysaccharides, des lipopolysaccharides, polynucléotides, de type ADN et ARN, et des glycoprotéines et des protéines, notamment des antigènes, des enzymes, des anticorps, des récepteurs et des hormones. En outre, l'Invaplex augmente la réaction immunitaire aux vaccins ADN et peut également être utilisé seul en tant que vaccin contre la shigellose.
Kaminski Robert W.
Oaks Edwin V.
Smart & Biggar
The Government Of The United States As Represented By The Secretary Of The Army
LandOfFree
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