Use of sigma receptor antagonists to enhance the effects of...

Details Use of sigma receptor antagonists to enhance the effects of... Use of sigma receptor antagonists to enhance the effects of...

A - Human Necessities

61

K

A61K 31/505 (2006.01) A61K 31/445 (2006.01) A61K 31/47 (2006.01) A61K 31/54 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2108480

2108480 9218127 PCTABS00016 The invention relates to a method of treating psychosis in a mammal which comprises administering to the mammal an effective amount of a dopamine receptor antagonist antipsychotic and a sigma receptor antagonist having greater affinity for sigma receptors than for dopamine receptors, in an amount effective to selectively enhance the antipsychotic effects of the dopamine receptor antagonist relative to the adverse side effects of the dopamine receptor antagonist.

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