Use of simple amino acids to form porous particles

Details Use of simple amino acids to form porous particles Use of simple amino acids to form porous particles

A - Human Necessities

61

K

A61K 9/16 (2006.01) A61K 9/72 (2006.01) A61K 47/18 (2006.01)

Patent

CA 2382651

Particles having a tap density of less than 0.4 g/cm3 include a hydrophobic amino acid or salt thereof and a therapeutic, prophylactic or diagnostic agent or any combination thereof. Preferred particles include a phospholipid, have a median geometric diameter between about 5 and about 30 microns and an aerodynamic diameter between about 1 and about 5 microns. The particles can be formed by spray-drying and are useful for delivery to the pulmonary system.

L'invention concerne des particules dont la densité après tassement est inférieure à 0,4 g/cm<3>, et qui comprennent un acide aminé hydrophobe ou un sel de celui-ci et un agent thérapeutique, prophylactique ou diagnostique, ou une combinaison de ceux-ci. Les particules préférées incluent un phospholipide, possédent un diamètre géométrique moyen d'environ 5 à 30 microns et un diamètre aérodynamique d'environ 1 à 5 microns. Les particules peuvent être formées par séchage par atomisation et sont utilisées pour l'administration dans un système pulmonaire.

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