A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/00 (2006.01) A61K 31/05 (2006.01) A61K 31/122 (2006.01) A61K 31/352 (2006.01) A61K 45/06 (2006.01) A61P 3/04 (2006.01) A61P 15/12 (2006.01)
Patent
CA 2595486
Provided herein are compositions and their use for treating and/or preventing flushing and/or weight gain by modulating the activity or level of a sirtuin, such as SIRTl or Sir2. Exemplary embodiments include compositions containing a sirtuin -activating compound and the use thereof for counteracting drug- induced weight gain and/or drug- induced flushing.
L'invention concerne des méthodes et des compositions destinées au traitement et/ou à la prévention des bouffées vasomotrices et/ou de la prise de poids. Ces méthodes peuvent consiter à moduler l'activité ou le niveau d'une sirtuine, telle que SIRT1 ou Sir2. Des modes de réalisation exemplaires concernent des méthodes et des compositions destinées à contrebalancer la prise de poids et/ou les bouffées vasomotrices d'origine médicamenteuse, par administration d'un composé d'activation de la sirtuine.
Langer Robert S.
Milburn Michael
Sinclair David
Westphal Christoph H.
Borden Ladner Gervais Llp
Sirtris Pharmaceuticals Inc.
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