A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/616 (2006.01) A61K 31/519 (2006.01) A61P 25/04 (2006.01) A61P 29/00 (2006.01) A61K 31/517 (2006.01)
Patent
CA 2493885
This invention relates to the use of combinations of a sodium channel blocking compound that binds to an SS1 or SS2 site of extracellular region of a sodium channel alpha subunit, and aspirin in manufacturing drugs for producing synergistically analgesic effect in mammals. Pharmaceutical compositions based upon this invention can enhance analgesic effect and reduce dosage of aspirin, therefore side effects and adverse reactions are decreased accordingly.
La présente invention concerne l'utilisation de combinaisons de composés bloquant les canaux sodiques et d'aspirine dans la production de médicaments destinés à obtenir un effet analgésique synergique chez des mammifères, chez qui lesdits composés se fixent à la sous-unité alpha des sites SS1 ou SS2 dans le canal sodique. Selon l'invention, les compositions pharmaceutiques ont un effet analgésique accru et par conséquent la posologie de l'aspirine ainsi que ses effets secondaires seraient réduits.
Ku Baoshan
Shum Hay Kong
Rapaport Lesley
Wex Medical Instrumentation Co. Ltd.
Wex Medical Limited
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