Use of soluble cd160 to suppress immunity

Details Use of soluble cd160 to suppress immunity Use of soluble cd160 to suppress immunity

A - Human Necessities

61

K

A61K 38/17 (2006.01) A61P 37/06 (2006.01)

Patent

CA 2658274

Pharmaceutical composition comprising a soluble form of CD160 for treating an inflammatory condition involving an undesired immune response, such as tissue graft or organ rejection, and autoimmune diseases; in vitro method for screening an individual for the presence of an inflammatory condition such as infectious and autoimmune diseases, tissue graft and organ rejection, or the presence of a tumor or activated endothelial cells, or for monitoring therapy of an inflammatory condition such as an autoimmune disorder or a tissue or organ rejection, or a tumor during chemotherapy including treatment with an anti- angiogenic substance or antibody.

L'invention concerne une composition pharmaceutique qui contient une forme soluble de CD160 et qui est destinée au traitement d'une pathologie inflammatoire impliquant une réponse immunitaire non souhaitée, telle qu'un rejet d'organe ou un rejet de greffe de tissu, et de maladies auto-immunes. L'invention concerne également une méthode in vitro permettant de dépister, chez un individu, la présence d'une pathologie inflammatoire, telle que des maladies infectieuses et auto-immunes, un rejet d'organe ou un rejet de greffe de tissu, ou la présence d'une tumeur ou de cellules endothéliales activées, ou permettant de surveiller le traitement d'une pathologie inflammatoire, telle qu'une maladie auto-immune ou un rejet d'organe ou de tissu, ou d'une tumeur au cours d'une chimiothérapie consistant à traiter la tumeur à l'aide d'une substance anti-angiogénique ou d'un anticorps.

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