C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/705 (2006.01) C12N 15/85 (2006.01)
Patent
CA 2386533
A new gene therapy entails tumor treatment by introducing an expressible nucleotide sequence for a soluble costimulatory factor, thereby enhancing the response of T-cells to a tumor. In vivo expression of the soluble factor overcomes anergy or tolerance to tumor cells and activates T-cells that are infiltrating or surrounding the tumor. A pharmaceutical composition containing such a gene is effective in tumor suppression.
La présente invention concerne un thérapie génique consistant à traiter une tumeur par introduction d'une séquence de nucléotide s'exprimant sous forme d'un facteur soluble co-stimulant, ce qui augmente la réponse de cellules T vis à vis d'une tumeur. L'expression du facteur soluble In vivo surmonte l'anergie ou la tolérance aux cellules tumorales et active les cellules T qui infiltrent ou qui sont autour de la tumeur. Une composition pharmaceutique contenant un tel gène est efficace dans la disparition de tumeur.
Martuza Robert L.
Rabkin Samuel D.
Todo Tomoki
Bereskin & Parr
Georgetown University
LandOfFree
Use of soluble costimulatory factor for tumor immuno-gene... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Use of soluble costimulatory factor for tumor immuno-gene..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of soluble costimulatory factor for tumor immuno-gene... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1555298