Use of soluble forms of cd83 and nucleic acids encoding them...

Details Use of soluble forms of cd83 and nucleic acids encoding them... Use of soluble forms of cd83 and nucleic acids encoding them...

C - Chemistry, Metallurgy

07

K

C07K 14/705 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) A61P 37/06 (2006.01) A61P 37/08 (2006.01) C12N 15/12 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2507373

The present invention provides for the use of soluble forms of CD83 and nucleic acids encoding them for the treatment of diseases caused by the dysfunction or undesired function of a cellular immune response involving dendritic cells, T cells and/or B cells. The invention moreover provides soluble CD83 molecules specifically suited for said purpose, antibodies against said specific soluble CD83 proteins and assay methods and kits comprising said antibodies.

L'invention concerne l'utilisation de formes solubles de CD83 et d'acides nucléiques codant pour CD83 afin de traiter ou de prévenir des maladies entraînées par le dysfonctionnement ou une fonction indésirable d'une réponse immunitaire impliquant des cellules dendritiques, des lymphocytes T et/ou des lymphocytes B. L'invention concerne également des molécules solubles CD83 spécifiquement appropriées pour l'utilisation précitée, des anticorps contre lesdites protéines solubles spécifiques CD83, t des méthodes de dosage et des kits comprenant lesdits anticorps.

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