Use of spiro-oxindole compounds as therapeutic agents

Details Use of spiro-oxindole compounds as therapeutic agents Use of spiro-oxindole compounds as therapeutic agents

A - Human Necessities

61

K

A61K 31/437 (2006.01) A61K 31/407 (2006.01) A61P 3/06 (2006.01) A61P 13/08 (2006.01) A61P 17/04 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2665698

This invention is directed to methods of using spiro-oxindole compounds of formula (I): wherein k, j, Q, R1, R2a, R2b, R2c, R2d, R3a, R3b, R3c, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, for the treatment and/or prevention of hypercholesterolemia, benign prostatic hyperplasia, pruritis and cancer.

Cette invention concerne l'utilisation, pour le traitement et/ou la prévention de l'hypercholestérolémie, de l'hyperplasie bénigne de la prostate, du prurit et du cancer, de composés de spiro-oxindole représentés par la formule (I). Dans cette formule, k, j, Q, R1, R2a, R2b, R2c, R2d, R3a, R3b, R3c, et R3d sont comme définis dans le descriptif, en tant que stéréoisomère, énantiomère, tautomère seuls ou en mélanges, ou bien un sel, un solvate ou un promédicament de qualité pharmaceutique de ces composés.

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