Use of statins (hmg-coa reductase inhibitors) for the...

A - Human Necessities – 61 – K

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Details

A61K 31/22 (2006.01) A61K 31/365 (2006.01) A61K 31/40 (2006.01) A61K 31/404 (2006.01) A61P 17/06 (2006.01) A61P 29/00 (2006.01) A61P 37/06 (2006.01)

Patent

CA 2422820

The present invention relates to methods of causing MHC-class II or CD40 mediated immunomodulation, immunosuppression and anti-inflammatory action, in a subject suffering from or susceptible of suffering from a condition involving inappropriate immune response, which comprises administering to the subject at least one statin, or a functionally or structurally equivalent molecule, in an amount effective to modulate MHC class II or CD40 expression in the subject.

La présente invention concerne des méthodes qui peuvent provoquer une immunomodulation, une immunosuppression ou une action anti-inflammatoire induites par HLA classe II ou CD40, chez un sujet atteint de ou susceptible d'être atteint d'une pathologie impliquant une réponse immunitaire inappropriée. Ces méthodes consistent à administrer au sujet au moins une statine, ou une molécule dont la fonction ou la structure est équivalente, en quantité effective pour moduler l'expression de HLA classe II ou CD40 chez le sujet.

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