Use of steroid hormones in compositions for inducing t cell...

C - Chemistry – Metallurgy – 12 – P

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C12P 21/02 (2006.01) A61K 31/56 (2006.01) A61K 31/565 (2006.01) A61K 31/57 (2006.01) A61K 31/59 (2006.01) A61K 39/02 (2006.01) A61K 39/12 (2006.01) A61K 45/06 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2066716

2066716 9104030 PCTABS00003 Disclosed is a method for enhancing the production of T cell lymphokines, which comprises exposing T cell lymphocytes which have a potential to make selected T cell lymphokines to an appropriate concentration of at least one particular steroid hormone prior to cellular activation. Also disclosed are applications of the method for clinically diagnosing abnormal interleukin production, maintaining in vitro tissue cultures of T cells, overcoming certain types of immunosuppression caused by elevated GCS levels, caused by endogenous production or exogenous administration, use as a vaccine adjuvant to selectively direct the vaccine-induced immune response down a protective, rather than a potentially pathologic or non-protective, immunologic pathway, as a treatment for naturally occurring aging-related decreases in immune function, as a treatment for stress or trauma-induced decreases in immune function, and as a means to facilitate desensitization to agents to which a warm-blooded animal is allergic.

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