Use of substance p antagonists for the treatment of chronic...

Details Use of substance p antagonists for the treatment of chronic... Use of substance p antagonists for the treatment of chronic...

A - Human Necessities

61

K

A61K 31/517 (2006.01) A61K 31/453 (2006.01) A61K 31/4709 (2006.01) A61K 31/4725 (2006.01) A61P 21/00 (2006.01)

Patent

CA 2339628

The invention relates to the pharmaceutical use of specific substance P antagonists, in particular 1-acylpiperidine substance P antagonists, especially N-benzoyl-2-benzyl-4-(azanaphthoyl-amino)- piperidines, e.g. of formula (I), wherein X and Y are each independently of the other N and/or CH and the ring A is unsubstituted or mono- or poly-substituted by substituents selected from the group consisting of lower alkyl, lower alkoxy, halogen, nitro and trifluoromethyl; and pharmaceutically acceptable salts thereof for treatment of chronic fatigue syndrome (CFS) in the absence of serotonin agonist/selective serotonin reuptake inhibitory therapy, or for the treatment of fibromyalgia or associated functional symptoms.

L'invention porte sur l'utilisation pharmaceutique d'antagonistes de substance P spécifiques, notamment d'antagonistes de substance P à base de 1-acylpipéridine, particulièrement de N-benzoyl-2-benzyl-4-(azanaphthoyl-amino)-pipéridines, par exemple de formule (I) dans laquelle X et Y représentent séparément N et/ou CH et le cycle A est non substitué ou mono- ou poly-substitué par des substituants choisis dans le groupe composé d'alkyle inférieur, d'alcoxy inférieur, d'halogène, de nitro et de trifluorométhyle ; et sur des sels acceptables au plan pharmaceutique, utilisés pour le traitement du syndrome de fatigue chronique en l'absence de thérapie inhibitrice spécifique du recaptage de la sérotonine/de l'agoniste de la sérotonine, ou pour le traitement de la cellulomyalgie ou de symptômes fonctionnels associés.

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