Use of substituted 1,2,4-oxadiazole derivatives for...

Details Use of substituted 1,2,4-oxadiazole derivatives for... Use of substituted 1,2,4-oxadiazole derivatives for...

C - Chemistry, Metallurgy

07

D

C07D 271/06 (2006.01) A01N 43/82 (2006.01) A61K 31/42 (2006.01) C07D 413/06 (2006.01)

Patent

CA 2058089

The present invention relates to new substituted 1,2,4- oxadiazole derivatives of the formula (I) and to their stereoisomers Image in which formula R1 represents hydrogen, C1-8-alkyl which is optionally substituted by halogen, cycloalkyl, alkoxy, hydroxyl, aryl, alkylcarbonyl, alkoxycarbonyl and cycloalkyl, R2 represents hydrogen, halogen, NO2, CN, alkyl, halo- genoalkyl, alkoxy or thioalkyl, R3 represents hydrogen, halogen, NO2, CN, alkyl, halo- genoalkyl, alkoxy or thioalkyl, R4 represents OH, SH, halogenoalkoxy, halogenoalkyl- thio, halogenoalkylsulphinyl, halogenoalkyl- sulphonyl, aryloxy, aralkoxy, arylthio, aralkylthio, alkylenedioxy, halogenoalkylenedioxy, amino, alkyl- amino, dialkylamino, acylamino, carbamoyl, alkylsulphinyl, alkylsulphonyl, arylsulphinyl, arylsulphonyl, sulphonylamino, alkoxycarbonyl, alkylcarbonyl, alkylcarbonyloxy, alkoxyalkyl, alkoxyalkoxy or hydroxyalkoxy, where, in the event that at least one of the radicals R2 or R3 is other than hydrogen, R4 additionally represents halogen, alkyl, halogenoalkyl, alkoxy or thioalkyl, where, in the event that R1 represents optionally substituted C1-8-alkyl, R4 additionally represents alkoxy, processes for their preparation, and their use as endo- parasiticides.

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