A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/41 (2006.01) A61K 31/00 (2006.01) A61K 31/19 (2006.01) A61K 31/33 (2006.01) A61K 31/34 (2006.01) A61K 31/38 (2006.01) A61K 31/395 (2006.01) A61K 31/40 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) A61K 31/55 (2006.01) A61K 31/695 (2006.01)
Patent
CA 2277490
Use of substituted 4-Biarylbutyric Acids and Derivatives as Matrix Metalloprotease Inhibitors having the generalized formula (T) x A-B-D-E-CO2H wherein A is an aryl or heteroaryl rings; B is an aryl or heteroaryl ring or a bond; each T is a substituent group; x is 0, 1, or 2; the group D represents (see above formula) the group E represents a two or three carbon chain bearing one to three substituent groups which are independent or are involved in ring formation, possible structures being shown in the text and claims; each of the substituents on E is an independent substituent; and include pharmaceutically acceptable salts thereof for the prevention and treatment of fibrotic diseases, in particular liver fibrosis and cirrhosis.
Hirth-Dietrich Claudia
Kluender Harold Clinton
Knorr Andreas
Kruse Christiane
Naab Paul
Borden Ladner Gervais Llp
Hirth-Dietrich Claudia
Kluender Harold Clinton
Knorr Andreas
Kruse Christiane
LandOfFree
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