Use of substituted 4-biarylbutyric and 5-biarylpentanoic...

Details Use of substituted 4-biarylbutyric and 5-biarylpentanoic... Use of substituted 4-biarylbutyric and 5-biarylpentanoic...

A - Human Necessities

61

K

A61K 31/192 (2006.01) A61K 31/195 (2006.01) A61K 31/24 (2006.01) A61K 31/4035 (2006.01) A61K 31/423 (2006.01) A61K 31/426 (2006.01) A61K 31/437 (2006.01) A61K 31/4406 (2006.01) A61K 31/4409 (2006.01) A61K 31/502 (2006.01) A61K 31/53 (2006.01) A61P 9/10 (2006.01) A61P 25/00 (2006.01) A61P 25/28 (2006.01) C07D 253/04 (2006.01)

Patent

CA 2333955

Use of subtsituted 4-Biarylbutyric and 5-Biarylpentanoic Acid Derivatives for the Treatment of Cerebral Diseases, pharmaceutical compositions containing them, and a process for using them. The compounds of the invention have the generalized formula (I): (T)xA-B-D-E-CO2H, wherein A is an aryl or heteroaryl rings; B is an aryl or heteroaryl ring or a bond; each T is a substituent group; x is 0,1, or 2; the group D represents (a), or (b), the group E represents a two or three carbon chain bearing one to three substituent groups which are independent or are involved in ring formation, possible structures being shown in the text and claims; and each of the substituents on E is an independent substituent; and includes pharmaceutically acceptable salts thereof.

Utilisation de dérivés substitués d'acides 4-biarylbutyrique et 5-biarylpentanoïque pour le traitement des maladies cérébrales, compositions pharmaceutiques contenant lesdits dérivés et méthode employée pour les utiliser. Les composants de l'invention ont la formule généralisée (I): (T)¿x?A-B-D-E-CO¿2?H, A étant un aryle ou des noyaux d'hétéroaryle; B étant un aryle ou un des noyaux d'hétéroaryle ou une liaison; chaque T étant un substituant; x étant 0,1, ou 2; le groupe D représentant (a), ou (b), le groupe E représentant une chaîne carbonée de deux ou trois comprenant un ou trois sustituant(s) qui sont indépendants ou compris dans la formation du noyau, les structures éventuelles figurant dans le texte et les revendications; et chacun des substituants présents sur E étant un substituant indépendant; et comprenant des sels pharmaceutiquement acceptables.

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