A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/428 (2006.01) A61K 31/165 (2006.01) A61K 31/198 (2006.01) A61P 25/16 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2458628
Substituted aminomethyl chromans, one of their optical isomers or pharmaceutically acceptable salts, used for the manufacture of a medicament for the treatment of adverse effects of anti-Parkinsonian drugs in extrapyramidal movement disorders and/or for the manufacture of a medicament for the treatment of extrapyramidal symptoms (EPS) induced by neuroleptics. A preferred compound is (-)-(R)-2-{4-[[3,4-dihydro-2H-benzopyran-2-yl)- methyl!amino!butyl}-1,2-benzoisothiazol-3-(2H)-on-1,1-dioxide or a physiologically acceptable salt thereof.
L'invention concerne les aminométhyle chromans à substitution ou un de leurs isomères optiques ou leurs sels pharmaceutiquement acceptables utilisés dans la fabrication d'un médicament destiné au traitement des effets secondaires de médicaments anti-Parkinsonien dans des troubles de mouvements extrapyramidaux et/ou pour la fabrication d'un médicament destiné au traitement de symptômes extrapyramidaux (EPS) induits par des neuroleptiques. Un composé préféré est le (-)-(R)-2-{4- 3,4-dihydro-2H-benzopyran-2-yl)-méthyl!amino!butyl}-1,2-benzoisothiazol-3-(2H)-on-1,1-dioxide ou un sel pharmaceutiquement acceptable de celui-ci.
Bartoszyk Gerd
Boettcher Henning
Bokel Heinz-Hermann
Russ Hermann
Schmid-Grossmann Uschi
Fetherstonhaugh & Co.
Merck Patent Gesellschaft Mit Beschraenkter Haftung
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