Use of substituted imidazoles

Details Use of substituted imidazoles Use of substituted imidazoles

A - Human Necessities

61

K

167/237

A61K 31/40 (2006.01) A61K 31/415 (2006.01)

Patent

CA 2027876

This invention relates to local epidural or intraspinal use of compounds of the formula: (see formula I) where X is H or CH3 and R1 and R2, which can be the same or different, are each H or CH3 and their stereoisomers and their non-toxic, pharmaceutically acceptable salts. Especially useful are the compounds known under the generic names medetomidine ((~)-4-[1-(2,3-dimethylphenyl)ethyl]- 1H-imidazole), dexmedetomidine (+)-4-[1-(2,3- dimethylphenyl)ethyl]-1H-imidazole and detomidine 4-(2,3- dimethylbenzyl)-1H-imidazole.

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