Use of sucrose to suppress mannitol-induced protein aggregation

Details Use of sucrose to suppress mannitol-induced protein aggregation Use of sucrose to suppress mannitol-induced protein aggregation

A - Human Necessities

61

K

A61K 9/10 (2006.01) A61K 38/00 (2006.01) A61K 39/395 (2006.01) A61K 47/26 (2006.01)

Patent

CA 2677937

The present invention provides a method for suppressing mannitol-induced protein aggregation by providing sucrose to a liquid formulation containing a protein. The present invention also provides methods for storing and preparing a liquid formulation containing a protein and a combination of mannitol and sucrose such that the presence of sucrose suppresses mannitol-induced protein aggregation.

L'invention concerne un procédé de suppression d'une agrégation de protéines provoquée par du mannitol en ajoutant du saccharose à une formulation liquide contenant une protéine. L'invention concerne également des procédés de stockage et de préparation d'une formulation liquide contenant une protéine et une combinaison de mannitol et de saccharose, de sorte que la présence de saccharose supprime l'agrégation de protéines provoquée par du mannitol.

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