Use of sulfamate derivatives for treating impulse control...

A - Human Necessities – 61 – K

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Details

A61K 31/255 (2006.01) A61K 31/18 (2006.01) A61K 31/351 (2006.01) A61K 31/36 (2006.01)

Patent

CA 2364949

Impulse Control Disorders (ICDs) are characterized by harmful behaviors performed in response to irresistible impulses. The essential feature of an ICD is the failure to resist an impulse, drive, or temptation and to perform an act that is harmful to the person or to others. The present invention comprises methods for the treatment or prevention of ICDs using a class of sulfamates of formula (I) wherein X is CH2 or oxygen, and R1, R2, R3, R4 and R5 are as herein defined. Further, pharmaceutical compositions containing a compound of formula (I) as well as methods for their use and intermediates form part of the present invention are also disclosed.

Les troubles du contrôle des pulsions se manifestent par des comportements dangereux en réaction à des pulsions auxquelles on ne peut pas s'opposer. En l'occurrence, les troubles du contrôle des impulsions se caractérisent, d'une part par l'impossibilité de résister à une pulsion, une envie ou une tentation, et d'autre part par des actes portant atteinte à soi-même ou à autrui. L'invention concerne plus particulièrement des procédures convenant au traitement ou à la prévention des troubles du contrôle des pulsions et impliquant l'utilisation d'une classe de sulfamates représentés par la formule (I). Dans cette formule, X est CH¿2? ou oxygène, et R¿1?, R¿2?, R¿3?, R¿4? et R¿5? sont tels que définis dans les spécifications. L'invention concerne enfin, des compositions pharmaceutiques contenant un composé représenté par la formule (I), les modes d'utilisation de ces compositions, et les intermédiaires correspondants.

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