A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/715 (2006.01) A61K 31/726 (2006.01) A61P 1/00 (2006.01) A61P 43/00 (2006.01)
Patent
CA 2447280
The present invention is directed to methods for preventing or treating inflammatory bowel disease by administering a composition comprising a therapeutically or prophylactically effective amount of a composition comprising between about 60% to 90% iduronylglycosaminoglycan sulfate and between about 10% to 40% dermatan sulfate, or a pharmaceutically acceptable salt, solvate, hydrate, or clathrate thereof. In a particular embodiment, a therapeutically or prophylactically effective amount of a composition comprising sulodexide, or a pharmaceutically acceptable salt, solvate, hydrate, or clathrate thereof is administered. The composition to be administered may also comprise one or more additional active ingredients selected from the group consisting of steroids, aminosalicylates, short-chain fatty acids, thioguanine derivatives, antibiotics, biological agents, antidepressants, and pain-relievers.
L'invention concerne des procédés permettant de prévenir ou de traiter une maladie entérique inflammatoire par administration d'une composition comprenant un quantité efficace au niveau thérapeutique ou prophylactique d'une composition comprenant entre environ 60 % à 90 % d'iduronylglycosaminoglycane sulfate et entre environ 10 % à 40 % de dermatane sulfate, ou d'un sel, solvate, hydrate, ou clathrate de ceux-ci pharmaceutiquement acceptables. Dans un mode de réalisation particulier de cette invention, une quantité efficace ou niveau thérapeutique ou prophylactique d'un composition comprenant du sulodexide, ou un sel, solvate, hydrate, ou clathrate pharmaceutiquement acceptables de celui-ci est administrée. Cette composition peut également comprendre au moins un ingrédient actif supplémentaire choisi dans le groupe comprenant stéroïdes, aminosalicylates, acides gras à chaîne courte, dérivés de thioguanine, antibiotiques, agents biologiques, antidépresseurs et analgésiques.
Laster Morris
Shelach Noa
Spero Michael
Keryx Biopharmaceuticals Inc.
Osler Hoskin & Harcourt Llp
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