Use of t-cadherin as a target

Details Use of t-cadherin as a target Use of t-cadherin as a target

C - Chemistry, Metallurgy

07

K

C07K 14/705 (2006.01) A61K 38/00 (2006.01) A61K 49/00 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2546126

This invention relates to the use of T-cadherin polypeptides for screening for modulators thereof, and to the use of said modulators for treating disorders selected from the group consisting of a metabolic disorder, a gynecologic disorder, a chronic inflammatory disorder and a liver or renal disorder. Metabolic disorders that may be treated using a modulator according to the present invention include, e.g., obesity, type II diabetes, insulin resistance, hypercholesterolemia, hyperlipidemia, dyslipidemia, syndrome X, cachexia and anorexia.

La présente invention concerne l'utilisation de polypeptides de T-cadhérine pour le criblage de modulateurs associés, ainsi que l'utilisation desdits modulateurs pour traiter des troubles sélectionnés dans le groupe comprenant : un trouble métabolique, un trouble gynécologique, un trouble inflammatoire chronique et un trouble hépatique ou rénal. Parmi les troubles métaboliques qui peuvent être traités à l'aide d'un modulateur selon la présente invention, on trouve, par exemple, l'obésité, le diabète de type II, la résistance à l'insuline, l'hypercholestérolémie, l'hyperlipidémie, la dyslipidémie, le syndrome X, la cachexie et l'anorexie.

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