Use of terfenadine derivatives as antihistaminics in a...

Details Use of terfenadine derivatives as antihistaminics in a... Use of terfenadine derivatives as antihistaminics in a...

A - Human Necessities

61

K

A61K 31/445 (2006.01)

Patent

CA 2134211

The present invention relates to a method of providing an antihistaminic effect in a hepatically impaired patient in need thereof comprising administering to said patient an effective antihistaminic amount of a compound of formula (1) wherein R1 is hydrogen or hydroxy; R2 is hydrogen; or R1 and R2 taken together form a second bond between the carbon atoms bearing R1 and R2; n is an integer of from 1 to 5; R3 is -COOH or -COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched; each of A and B is hydrogen or hydroxy with the proviso that at least one of A or B is hydrogen; or a pharmaceutically acceptable salt and individual isomers thereof.

L'invention a trait à un procédé permettant de susciter un effet antihistaminique nécessaire à un patient souffrant de troubles hépatiques. Elle consiste à lui administrer en quantité efficace sur le plan antihistaminique un composé de formule (I), où R1 représente hydrogène ou hydroxy; R2 représente hydrogène; ou bien R1 et R2 conjointement forment une deuxième liaison entre les atomes de carbone qui les portent; n est un nombre entier allant de 1 à 5; R3 représente -COOH ou -COOalkyle où la fraction alkyle comporte 1 à 6 atomes de carbone sous forme droite ou ramifiée; A et B représentent chacun hydrogène ou hydroxy à condition que l'un au moins représente hydrogène. On décrit en outre un sel de ce dérivé qui est pharmaceutiquement acceptable et des isomères individuels de ce sel.

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