Use of terpenes and derivatives as potentiators of antitumor...

Details Use of terpenes and derivatives as potentiators of antitumor... Use of terpenes and derivatives as potentiators of antitumor...

A - Human Necessities

61

K

A61K 31/337 (2006.01) A61K 31/015 (2006.01) A61K 45/06 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2356438

The present invention relates the employment of terpenes including mono-, di-, sesqui-, triterpene and derivatives as potentiators of various antitumor agents in the treatment of cancers. Terpenes and derivatives are used in combination with antitumor agents to increase their antitumor activity in vitro and in vivo. Using of terpenes and/or derivatives showed to increase the transport across the plasma membrane of mammalian cells and/or to decrease the intracellular glutathione which is implicated in the detoxification of various xenobiotics including antitumor agents and in the resistance of tumors.

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