Use of tetracyclines for treating meibomian gland disease

Details Use of tetracyclines for treating meibomian gland disease Use of tetracyclines for treating meibomian gland disease

A - Human Necessities

61

K

A61K 31/65 (2006.01)

Patent

CA 2331257

A method for treating a patient having meibomian gland disease, ocular irritation associated with delayed tear clearance, or recurrent corneal epithelial erosion, is disclosed. Preferably, the method concerns treatment of a patient with topical tetracycline, a derivative or analogue of tetracycline, or a chemically modified tetracycline (CMT). Oral administration of a CMT is also disclosed as part of the method for treating meibomian gland disease, ocular irritation associated with delayed tear clearance, or recurrent corneal epithelial erosion.

L'invention concerne un procédé de traitement d'un patient souffrant de la maladie de la glande de Meibomius, d'irritation oculaire associée au retard de la clairance des larmes ou d'érosion récidivante épithéliale de la cornée. Ce procédé consiste de préférence à traiter un patient avec de la tétracycline topique, avec un dérivé ou un analogue de la tétracycline ou encore avec une tétracycline chimiquement modifiée (CMT). Ce procédé consiste aussi à administrer par voie orale de la CMT pour traiter la maladie de la glande de Meibomius, l'irritation oculaire associée au retard de la clairance des larmes ou l'érosion épithéliale récidivante de la cornée.

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