Use of texaphyrins in macrophage-mediated disease

Details Use of texaphyrins in macrophage-mediated disease Use of texaphyrins in macrophage-mediated disease

A - Human Necessities

61

K

A61K 41/00 (2006.01) A61K 49/00 (2006.01)

Patent

CA 2336134

The present invention provides methods for treating disease of a subject in need thereof by sensitizing the effects of a co-therapeutic agent in macrophages. The method comprises administering a texaphyrin and a co- therapeutic agent to the subject. Texaphyrins are provided for enhancing the cytotoxicity of therapeutic agents in macrophage-mediated disease since texaphyrins have been shown to accumulate in macrophage.

La présente invention concerne des procédés permettant de traiter une maladie chez un sujet qui en a besoin en sensibilisant les macrophages aux effets d'un agent co-thérapeutique. Le procédé de l'invention consiste à administrer une texaphyrine et un agent co-thérapeutique au patient. Les texaphyrines, dont il a été démontré qu'elles s'accumulent dans les macrophages, permettent de renforcer la cytotoxicité des agents thérapeutiques dans les maladies à médiation macrophagique.

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