A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4439 (2006.01) A61K 31/00 (2006.01) A61K 31/42 (2006.01) A61K 31/421 (2006.01) A61K 45/00 (2006.01) A61P 3/06 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) C07D 263/32 (2006.01) C07D 401/14 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2445322
The ABCA1 mRNA expression-promoting agent, LXR.alpha. mRNA expression-promoting agent, ABCG1 mRNA expression-promoting agent, cholesterol efflux-promoting agent, cholesteryl ester accumulation-inhibiting agent, ACAT-1 mRNA expression-inhibiting agent and CEH mRNA expression-promoting agent of the present invention are excellent in the ability to control cholesterol distribution in the body and have low toxicity. The ABC expression promoting agent pioglitazone, or a salt thereof, is used for the treatment of arteriosclerosis obliterans.
Promoteurs d'expression d'ABC-A1 ARNm, promoteurs d'expression d'LXR.alpha. ARNm, promoteurs d'expression d'ABC-G1 ARNm, promoteurs de transport de cholestérol et inhibiteurs d'accumulation de transport de cholestérol contenant des modulateurs de PPAR.delta. tels que pioglitazone; promoteurs d'expression d'ABC-G1 ARNm contenant des modulateurs de PPAR.delta.; ou promoteurs d'expression d'ACAT-1 ARNm et promoteurs d'expression de CEH ARNm contenant des modulateurs de PPAR.delta. tels que pioglitazone. Ces agents ont une excellente capacité de contrôle de la répartition du cholestérol in vivo et possèdent une faible toxicité.
Fuse Hiromitsu
Hirakata Masao
Sugiyama Yasuo
Tozawa Ryuichi
Fetherstonhaugh & Co.
Takeda Chemical Industries Ltd.
Takeda Pharmaceutical Company Limited
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