Use of the cathelicidin ll-37 and derivatives thereof for...

Details Use of the cathelicidin ll-37 and derivatives thereof for... Use of the cathelicidin ll-37 and derivatives thereof for...

A - Human Necessities

61

K

A61K 38/17 (2006.01) C12N 5/071 (2010.01) A61K 9/70 (2006.01) A61K 48/00 (2006.01) A61P 17/02 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2513598

Use of the antimicrobial cathelicidin peptide ll-37, N-terminal fragments of LL-37 or extended sequences of LL-37 having 1-3 amino acids in the C-terminal end, for stimulating proliferation of epithalial and stromal cells and thereby healing of wounds, such as chronic ulcers. The cytotoxic effect of LL-37 may be reduced by including a bilayer-forming polar lipid, especially a digalactosyldiacylglycerol, in pharmaceutical compositions and growth media comprising LL-37.

L'invention concerne l'utilisation du peptide de cathélicidine antimicrobien LL-37, de fragments N-terminaux de LL-37 ou de séquences étendues de LL-37 présentant des acides aminés 1-3 sur l'extrémité C-terminal, pour stimuler la prolifération de cellules épithéliales et stromales, et par conséquent pour stimuler la cicatrisation de plaies, notamment des ulcères chroniques. L'effet cytotoxique de LL-37 peut être réduit en intégrant un lipide polaire de formation bicouche, en particulier un digalactosyldiacylglycérol, dans des compositions pharmaceutiques, et un support de croissance comprenant LL-37.

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