A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4188 (2006.01) A61K 38/19 (2006.01) A61K 49/00 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2577550
Disclosed are methods of synergistically inhibiting growth of a glioma cell comprising contacting the cell with temozolomide and TNF.alpha., or with temozolomide, TNF.alpha., and radiation. Also disclosed are methods of synergistically inhibiting growth of a glioma in a human cancer patient comprising administering temozolomide and TNF.alpha., or with temozolomide, TNF.alpha., and radiation. Pharmaceutical combinations and therapeutic combinations suitable for use in the methods of the invention are also disclosed.
L'invention concerne des méthodes destinées à inhiber, de manière synergique, la croissance d'une cellule gliomale et consistant à mettre cette cellule en contact avec du témozolomide et un TNF.alpha., ou avec du témozolomide, un TNF.alpha. et un rayonnement. L'invention concerne également des méthodes destinées à inhiber, de manière synergique, la croissance d'un gliome chez un patient cancéreux humain et consistant à administrer du témozolomide et un TNF.alpha. ou à utiliser du témozolomide, un TNF.alpha. et un rayonnement. L'invention concerne également des combinaisons pharmaceutiques et des combinaisons thérapeutiques pouvant être utilisées dans ces méthodes.
Kufe Donald W.
Weichselbaum Ralph R.
Yamini Bakhtiar
Dana-Farber Cancer Institute Inc.
The University Of Chicago
Torys Llp
LandOfFree
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