Use of the disintegrin domain of an adamalysin as...

A - Human Necessities – 61 – K

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Details

A61K 38/48 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) A61P 9/10 (2006.01) A61P 17/06 (2006.01) A61P 27/00 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07K 14/705 (2006.01) C12N 9/64 (2006.01) C12N 15/12 (2006.01) C12N 15/57 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2453561

The invention concerns the use, in preparing a medicine for inhibiting angiogenesis or invasion and/or formation of metastases, of an active agent selected among a proteinic substance comprising or consisting of all or part of the disintegrin domain of an adamalysin or a derivative thereof, a nucleic acid molecule comprising or consisting of a polynucleotide sequence encoding all or part of the disintegrin domain of an adamalysine or a derivative thereof. Advantageously, the adamalysin is metargidin.

La présente invention concerne l'utilisation, dans la préparation d'un médicament pour inhiber l'angiogénèse ou l'invasion et/ou la formation de métastases, d'un agent actif choisi parmi une substance protéique comprenant ou constituée de tout ou partie du domaine disintégrine d'une adamalysine ou un dérivé de celui-ci, une molécule d'acide nucléique comprenant ou constituée d'une séquence polynucléotidique codant tout ou partie du domaine disintégrine d'une adamalysine ou un dérivé de celui-ci. Avantageusement, l'adamalysine est la métargidine.

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