Use of the enantiomer (1s, 2r) of milnacipran for the...

A - Human Necessities – 61 – K

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A61K 31/135 (2006.01) A61K 31/165 (2006.01) A61K 31/167 (2006.01) A61K 31/195 (2006.01) A61K 31/4015 (2006.01)

Patent

CA 2514948

The invention relates to the use of an enantiomer mixture which is enriched in the enantiomer (1S, 2R) of Milnacipran and/or at least one of the metabolites thereof, as well as the pharmaceutically-acceptable salts of same, for the preparation of a medicament which is intended to prevent or treat pathologies that can be cured through the dual inhibition of the recapture of serotonin (5-HT) and noradrenaline (NA), while limiting the risks of cardiovascular disorders and/or tissue and/or organic toxicity.

La présente invention concerne l'utilisation d'un mélange d'énantiomères enrichi en énantiomère (1S,2R) du Milnacipran et/ou d'au moins un de ses métabolites, ainsi que leurs sels pharmaceutiquement acceptables, pour la préparation d'un médicament destiné à prévenir ou traiter des pathologies pouvant être soignées par l'inhibition double de la recapture de la sérotonine (5-HT) et de la noradrénaline (NA), tout en limitant les risques de troubles cardiovasculaires et/ou de toxicité organique et/ou tissulaire.

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