Use of the gm monosialoganglioside and of its internal ester...

A - Human Necessities – 61 – K

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A61K 31/70 (2006.01) A61K 35/30 (2006.01)

Patent

CA 2045982

ABSTRACT A new use of monosialoganglioside GM1 of its pharmacologically acceptable salts and of its internal ester derivative for the preparation of pharmaceutical compositions apt to prevent the insurgence in man of the tolerance to the analgesic effect of morphine, of chemically correlated opiates, of methadone and its derivatives is described.

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