G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/574 (2006.01) C12N 15/113 (2010.01)
Patent
CA 2761856
The present invention relates to evaluating the prognosis of patients with estrogen receptor- positive breast cancer on the basis of Rab27B expression. The invention further relates to a kit comprising an assay for measuring Rab27B levels in said patients and to the usage of Rab27B as a target to screen for drugs capable of inhibiting or diminishing metastasis of said cancer. Furthermore, the invention discloses compounds which can be used to treat estrogen receptor- positive breast cancer.
La présente invention porte sur l'évaluation du pronostic de patientes atteintes d'un cancer de sein positif au récepteur de l'estrogène, sur la base de l'expression de Rab27B. L'invention porte en outre sur un kit renfermant un dosage pour mesurer les taux de Rab27B dans lesdites patientes et sur l'utilisation de Rab27B en tant que cible pour cribler des médicaments capables d'inhiber ou de diminuer les métastases dudit cancer. En outre, l'invention porte sur des composés qui peuvent être utilisés pour traiter un cancer du sein positif au récepteur de l'estrogène.
de Wever Olivier
Hendrix An
Westbroek Wendy
Borden Ladner Gervais Llp
Universiteit Gent
LandOfFree
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