Use of the heat shock protein gp96

Details Use of the heat shock protein gp96 Use of the heat shock protein gp96

A - Human Necessities

61

K

A61K 38/17 (2006.01) A61K 39/00 (2006.01) A61P 35/00 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2415434

The invention relates to the use of gp96 molecules that carry no antigens of interest, for marking and/or activating antigen-presenting cells (APCs), for example dendritic cells, monocytes, macrophages, B cells and peritoneal exudation cells. Said APCs can be loaded with antigens once they have been activated and are used to induce an immune response, or in tumor therapy.

L'invention concerne l'utilisation de molécules gp96 ne portant pas d'antigènes d'intérêt, pour le marquage et/ou l'activation de cellules présentant des antigènes (APC), telles que des cellules dendritiques, des monocytes, des macrophages, des cellules B, et des cellules d'exsudation péritonéale. Après activation, ces cellules présentant des antigènes peuvent être chargées d'antigènes, et employées pour produire une réaction immunitaire ou dans le cadre d'une thérapie tumorale.

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