Use of the interferon receptor 2c polypeptide chain to...

Details Use of the interferon receptor 2c polypeptide chain to... Use of the interferon receptor 2c polypeptide chain to...

A - Human Necessities

61

K

A61K 38/21 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) A61P 9/10 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2416358

The present invention is directed towards a method of potentiating the anti- growth effects of type I interferon (IFN) on cells in a target cell population comprising increasing the number of functional IFNAR2c receptors on the surface of modified cells within the target cell population and then exposing the modified cells to a therapeutically effective amount of a type I IFN or by exposure to endogenously produced IFN.

L'invention concerne un procédé destiné à potentialiser les effets anti-croissance de l'interféron de type I (IFN) sur des cellules dans une population cellulaire, qui consiste à augmenter le nombre de récepteurs IFNAR2c sur la surface des cellules modifiées à l'intérieur de la population cellulaire cible et à exposer les cellules modifiées à une dose thérapeutiquement efficace de l'IFN de type I ou à l'IFN produit de manière endogène.

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