Use of the lipoxin receptor, fprl1, as a tool for...

Details Use of the lipoxin receptor, fprl1, as a tool for... Use of the lipoxin receptor, fprl1, as a tool for...

G - Physics

01

N

G01N 33/50 (2006.01)

Patent

CA 2544983

Disclosed herein are compounds that selectively activate the FPRL1 receptor. Further disclosed are methods of alleviating inflammatory responses by regulating key steps in leukocyte trafficking and preventing neutrophil- mediated tissue damage by administering to a subject a therapeutically effective amount of the compounds disclosed herein. In addition, methods of modulating, or specifically agonizing, the FPRL1 receptor by administering an effective amount of the compounds disclosed herein are provided.

L'invention concerne des composés qui activent de manière sélective le récepteur FPRL1. L'invention concerne également des procédés destinés à soulager des réactions inflammatoires par régulation d'étapes clés dans le commerce illicite de leucocytes et dans la prévention de dommages tissulaires induits par des neutrophiles par administration à un sujet d'une quantité efficace sur le plan thérapeutique des composés de cette invention. En outre, cette invention concerne des procédés de modulation ou de production d'une action agoniste spécifique du récepteur FPRL1 par administration d'une quantité efficace des composés susmentionnés.

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