Use of the opposite cell differentiation program (ocdp) for...

A - Human Necessities – 61 – K

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A61K 35/37 (2006.01) C12N 5/071 (2010.01) A61K 35/12 (2006.01)

Patent

CA 2699624

The present invention relates to a method for the treatment of organs which are degenerative and /or in the pathological state by means of the use of cells, which are phenotypically stably differentiating or differentiated but not necessarily ultimately predetermined with respect to development, from a donor organ selected according to the principles of the opposite cell differentiation program (OCDP) and also to the use of cells of this type for the treatment or for the production of a drug for treatment of the same. Furthermore, the present invention relates to pharmaceutical agents comprising suitable phenotypically stable cells, cells of a first organ which is different from the second organ with respect to organ type thereby being used, which, in the normal physiological state with respect to a predetermined set of expressed genes and/ or phenotypical properties, have opposite properties to the second cells in the normal physiological state.

La présente invention porte sur un procédé de traitement d'organes qui sont dégénératifs et/ou à l'état pathologique au moyen de l'utilisation de cellules, qui se différencient ou sont différenciées de façon phénotypiquement stable, mais non nécessairement prédéterminées de façon ultime en ce qui concerne un développement, à partir d'un organe donneur choisi conformément aux principes du programme de différenciation cellulaire opposée (OCDP). L'invention porte également sur l'utilisation de cellules de ce type pour le traitement ou pour la production d'un médicament pour le traitement de celles-ci. De plus, la présente invention porte sur des agents pharmaceutiques comprenant des cellules phénotypiquement stables appropriées, des cellules d'un premier organe qui est différent du second organe en ce qui concerne le type d'organe qui est ainsi utilisé, lequel, dans l'état physiologique normal en ce qui concerne un ensemble prédéterminé de gènes exprimés et/ou de propriétés phénotypiques, ont des propriétés opposées aux secondes cellules dans l'état physiologique normal.

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