Use of the receptor gpr86

Details Use of the receptor gpr86 Use of the receptor gpr86

G - Physics

01

N

G01N 33/566 (2006.01) C07K 14/705 (2006.01)

Patent

CA 2572547

We disclose a method of identifying a molecule suitable for the treatment, prophylaxis or alleviation of a GPR86 associated disease, in particular inflammatory disease or pain, the method comprising determining whether a candidate molecule is an agonist or antagonist of GPR86 polypeptide, in which the GPR86 polypeptide comprises the amino acid sequence shown in SEQ ID NO. 3 or SEQ ID NO: 5 or SEQ ID NO: 7, a fragment thereof or a sequence which is at least 90% identical thereto.

L'invention concerne un procédé pour identifier une molécule apte au traitement, à la prophylaxie et à l'atténuation d'un trouble associé à GPR86, en particulier d'une maladie ou d'une douleur inflammatoire. Ce procédé consiste à déterminer si une molécule candidate est une agoniste ou une antagoniste du polypeptide de GPR86, le polypeptide de GPR86 comprenant la séquence d'acide aminé présentée dans SEQ ID NO. 3 ou SEQ ID NO: 5 ou SEQ ID NO: 7, dont un fragment ou une séquence est identique à au moins 90 %.

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