Use of thiazolidinone derivatives as antiangiogenic agents

Details Use of thiazolidinone derivatives as antiangiogenic agents Use of thiazolidinone derivatives as antiangiogenic agents

C - Chemistry, Metallurgy

07

D

C07D 417/06 (2006.01) A61K 31/427 (2006.01) A61K 31/5377 (2006.01) A61P 35/00 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2592004

The invention relates to the use of compounds of general formula (I), in which R1, R2 and X are as defined in the description for the preparation of pharmaceutical compositions for the treatment of pathologies in which inhibition of the interaction between HIF-1.alpha. and p300 is beneficial, in particular as antiangiogenic medicaments for the therapy of solid tumors.

L'invention concerne l'utilisation de composés de formule générale (I), dans laquelle R1, R2 et X sont tels que définis dans la description, pour la préparation de compositions pharmaceutiques destinées à traiter des pathologies dans lesquelles une inhibition de l'interaction entre HIF-1.alpha. et p300 est bénéfique, en particulier comme médicaments antiangiogéniques en traitement de tumeurs solides.

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