Use of thiazolo-[2,3-a]-isoindole derivatives as antiviral...

C - Chemistry – Metallurgy – 07 – D

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C07D 513/04 (2006.01) A61K 31/395 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2100366

2100366 9213863 PCTABS00014 The object of the present invention is the use of thiazolo-[2,3-a]isoindole derivatives for the production of antiviral medicaments and novel thiazolo-[2,3-a]isoindole derivatives. The invention relates in particular to the use of thiazolo-[2,3-a]isoindole derivatives of general formula (I) for the production of medicaments for the treatment of viral or retroviral infections, wherein: X may be an oxygen or sulphur atom, the imino group =NH or an N-C1-C5-alkylimino group; n is 0, 1 or 2; R is a hydrogen atom, an aliphatic radical or an optionally substituted carbocyclic or heterocyclic ring; R1 to R6 have the meaning given in the description; and their tautomers, enantiomers, diastereomers and physiologically acceptable salts. The present invention also discloses novel thiazolo-[2,3-a]isoindoles of formula (I) in which R is a heterocyclic mono, bi or tricyclic ring.

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