Use of thio-oxindole derivatives in treatment of...

A - Human Necessities – 61 – K

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A61K 31/40 (2006.01) A61K 31/404 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2489813

The present invention provides methods of inducing contraception which includes delivering to a female a composition containing a compound of formula (I), or tautomers thereof, in a regimen which involves delivering one or more of a selective estrogen receptor modulator, wherein formula (I) and wherein R1- R5 and Q1 are defined as described herein. Methods of providing hormone replacement therapy and for treating carcinomas, dysfunctional bleeding, uterine leiomyomata, endometriosis, and polycystic ovary syndrome is provided which includes delivering a compound of formula I and a selective estrogen receptor modulator are also described.

L'invention concerne des méthodes contraceptives qui consistent à administrer à une femme une composition contenant un composé représenté par la formule (I) ( dans laquelle R?1¿-R?5¿ et Q?1¿ sont tels que définis dans le descriptif), ou des tautomères de celui-ci, dans le cadre d'un schéma posologique qui implique l'administration d'au moins un modulateur sélectif des récepteurs oestrogéniques MSRO. L'invention concerne par ailleurs des méthodes de traitement hormonal substitutif destinées à traiter les carcinomes, la ménométrorragie, la leiomyomatose utérine, l'endométriose et le syndrome de Stein-Leventhal, et qui consistent à administrer un composé de formule (I) associé à un MSRO.

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