Use of threonine for the treatment of phenylketonuria

A - Human Necessities – 61 – K

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A61K 38/17 (2006.01) A23C 9/20 (2006.01) A23L 1/305 (2006.01) A61K 31/195 (2006.01) A61K 31/198 (2006.01) A61K 38/01 (2006.01)

Patent

CA 2232134

The invention relates to the use of threonine for the treatment of phenylketonuria (PKU). The invention is based on the surprising discovery that the concentration of phenylalanine in the plasma of PKU patients can be reduced by additional doses of threonine. The object of the invention is therefore an agent for dietetic or pharmaceutical use in case of phenylketonuria, which agent contains at least 8 g threonine per 100 g amino acids. This agent may be foods, in particular formula foods and PKU dietary foods.

L'invention concerne l'utilisation de la thréonine pour le traitement de la phénylcétonurie. L'invention est fondée sur la découverte surprenante que la concentration de phénylalanine dans le plasma de patients souffrant de phénylcétonurie peut être réduite par des doses additionnelles de thréonine. L'objet de l'invention est donc un agent destiné à un usage diététique ou pharmaceutique en cas de phénylcétonurie, ledit agent contenant au moins 8 g de thréonine pour 100 g d'aminoacides. Cet agent peut se présenter sous la forme d'aliments, en particulier d'aliments formulés et d'aliments diététiques pour le traitement de la phénylcétonurie.

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