Use of tigecycline, alone, or in combination with rifampin...

A - Human Necessities – 61 – K

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Details

A61K 31/496 (2006.01) A61K 31/65 (2006.01) A61P 19/02 (2006.01) A61P 31/04 (2006.01)

Patent

CA 2537281

The present invention is directed to a method for treating bone or bone marrow infections, joint infection or infection of the tissues surrounding the joint by administration of the antibiotic tigecycline alone or in combination with a rifamycin antibiotic. In a preferred embodiment the bone or bone marrow infection causes osteomyelitis. In another embodiment the joint infection or infection of the tissues surrounding the joint causes septic arthritis. The invention is also directed to manufacture of a medicament for treatment of bone and/or bone marrow infections, or joint infections and/or infections in tissues surrounding the joint with tigecycline alone or in combination with rifampin.

La présente invention concerne un procédé permettant de traiter des infections de l'os ou de la moelle osseuse, l'infection des articulations ou l'infection des tissus entourant l'articulation, par antibiothérapie à base de tigécycline seule ou associée à rifamycine. Dans un mode de réalisation préféré, l'infection de l'os ou de sa moelle provoque l'ostéomyélite. Dans un autre mode de réalisation, l'infection articulaire ou des tissus entourant l'articulation provoque l'arthrite septique. L'invention concerne également la fabrication d'un médicament destiné au traitement des infections de l'os et/ou de sa moelle, ou d'infections des articulations et/ou des tissus les entourant, ce médicament étant à base de tigécycline seule ou associée à la rifampine.

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