Use of tm-601 for the diagnosis and treatment of tumors

Details Use of tm-601 for the diagnosis and treatment of tumors Use of tm-601 for the diagnosis and treatment of tumors

C - Chemistry, Metallurgy

07

K

C07K 14/435 (2006.01) A61K 31/00 (2006.01) A61K 38/17 (2006.01)

Patent

CA 2647907

The present invention is directed to methods and compositions for the - treatment and diagnosis of neuroectodermally-derived tumors, such as gliomas. The inventive methods of treatment generally include local (e.g., intracavitary) administration of a chloroxotoxin moiety conjugated to a cytotoxic moiety to a patient. Also provided are diagnostic methods for screening neoplastic neuroectodermal tumors.

La présente invention concerne des méthodes et des compositions pour le traitement et le diagnostic de tumeurs dérivées du neuro-ectoderme, telles que les gliomes. Les méthodes de traitement de l'invention incluent généralement l'administration locale (par exemple, intracavitaire) à un patient d'un fragment chlorotoxine conjugué à un fragment cytotoxique. L'invention concerne également des méthodes diagnostiques pour dépister des tumeurs neuro-ectodermales néoplasiques.

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